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In hairy cell leukemia, the "hairy cells" (malignant B lymphocytes) accumulate in the bone marrow, interfering with the production of normal white blood cells , red blood cells , and platelets . Consequently, patients may develop infections related to low white blood cell count , anemia and fatigue due to a lack of red blood cells, or easy bleeding due to a low platelet count . [2] Leukemic cells may gather in the spleen and cause it to swell; this can have the side effect of making the person feel full even when he or she has not eaten much.

Although most lesions of this type show an NK lineage (as evident by CD3s-negative, CD56-positive germline T-cell receptor status), some cases may show a cytotoxic T-cell phenotype, and hence, the designation of NK/T-cell lymphoma. Other entities of putative NK lineage but EBV-negative (eg, chronic T- and NK-cell lymphocytosis, plasmacytoid dendritic-cell tumors, and NK/myeloid leukemia) are pathogenetically unrelated.


Leukemia dating

Leukemia dating